Synthesis, Characterization of Some New 2-Azetidinone.
In this communication, we wish to present an easy entry towards 2,4-unsubstituted azetidin-3-ones 9 starting from N-(alkylidene)- or N-(arylidene)-2,2,3-tribromopropylamines 6.The new tribromoimines 6 were synthesized from 2-bromoallylamine 4, which can easily be synthesized via a well-established procedure, starting from allyl bromide. 16 Two pathways can be followed in the synthesis of.Structure, properties, spectra, suppliers and links for: 3-Azetidinone.Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in rats, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.
This research Involved synthesis of some new azetidinone Derivatives from Azo Compound(4-Amino-3--((4-methoxy-2-nitrophenyl)diazenyl)-N-(Pyrimidine-2-yl)benzen-esulfonamide)(N1)by two routsone of them Convers-ion the free amino group in an azo comp. to Schiff base, then formation of azetidinone derivatives by keten-imine.Scheme I. Synthesis of the 2 -Azetidinone derivatives 5(a e) World Scientific News 92(2) (2018) 247-259 -250- On cooling the product, acid hydrazide separates out. It was filtered and collected. Recrystallization was carried out with ethanol and physical data was noted. The physical properties of synthesized derivatives 3(a-e) are shown in Table 1. Table 1. Physical properties and IR Spectral.
Rapid and efficient synthesis of newer heterocyclic 2-azetidinone and 5-benzylidine-4-oxo-thiazolidine compounds and their pharmacological studies. Chemistry International 3(2) (2017) 123-134. INTRODUCTION Over the past years, potency of antimicrobial therapy is somewhat in hesitate due to bacterial resistance to antibiotics. Quick development of drug resistant strains exerts a severe threat.
